Mast cells are localized through the entire body and mediate allergic, immune, and inflammatory reactions
Mast cells are localized through the entire body and mediate allergic, immune, and inflammatory reactions. release of corticotropin-releasing hormone (CRH) from paraventricular nucleus of hypothalamus and mast cells. CRH activates glial cells and mast cells through CRH receptors and releases neuroinflammatory mediators. Stress also increases proinflammatory mediator release in the peripheral systems that can induce…