The prodrug is subject to enzymatic hydrolysis by phospholipase A2 (PLA2) and non-specific esterases yielding the parent dihydrofuran allocolchicinoid (aC)
The prodrug is subject to enzymatic hydrolysis by phospholipase A2 (PLA2) and non-specific esterases yielding the parent dihydrofuran allocolchicinoid (aC). In circulation, liposomes of pure ePC bind considerable amount of proteins gaining the so-called protein corona and are rapidly removed by mononuclear phagocyte system (also known as reticular endothelial system, RES) [18]. the /-tubulin heterodimers…