(C) Projection of pachytene nuclei labeled by FISH with 5S rDNA probe and stained with DAPI
(C) Projection of pachytene nuclei labeled by FISH with 5S rDNA probe and stained with DAPI. REC-8 complexes provide stable cohesion. Surprisingly, a WAPL-1-impartial mechanism removes cohesin before metaphase I. Our studies provide insight into how meiosis-specific cohesin complexes are regulated to ensure formation of euploid gametes. DOI: http://dx.doi.org/10.7554/eLife.10851.001 germ line, which contains a complete…